Phosphorus oxychloride → HCID 11375509, compound

Participants

Reaction Steps

In a similar manner as described for Example 1, 2-[(trifluoroacetyl)amino]-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (Intermediate 16) (0.118 g, 0.23 mmol) in 1,2-dichloroethane (30 mL) and phosphorus oxychloride (1.0 mL, 11 mmol) gave 2,2,2-trifluoro-N-(2-{5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-7-yl}phenyl)acetamide (0.012 g) as a yellow solid. 1H NMR (CDCl3): δ13.87 (s, 1H), 8.91 (dd, J=8.0, 1.4 Hz, 1H), 8.88 (s, 1H), 8.63 (dd, J=8.4, 1.1 Hz, 1H), 7.47-7.41 (m, 1H), 7.28-7.22 (m, 1H), 7.08 (s, 1H), 6.86 (s, 2H), 3.85 (s, 3H), 3.80 (s, 6H), 2.60 (s, 3H). MS m/z 503 (M+1).

Provenance & Evidence