Phosphorus oxychloride → HCID 11395918, compound

Participants

Reaction Steps

In a similar manner as described for Example 1,3-cyano-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (Intermediate 17) (0.12 g, 0.25 mmol) in 1,2-dichloroethane (20 mL) and phosphorus oxychloride (0.28 mL, 3.0 mmol) gave 3-{5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]-imidazo[5,1-f][1,2,4]triazin-7-yl}benzonitrile (0.023 g) as a yellow solid. 1H NMR (CDCl3): δ8.84 (s, 1H), 8.79 (d, J=8.1 Hz, 1H), 8.74 (s, 1H), 7.64 (d, J=7.9 Hz, 1H), 7.54 (dd, J=7.9, 7.8 Hz, 1H) 7.09 (s, 1H), 6.83 (s, 2H), 3.85 (s, 3H), 3.81 (s, 6H), 2.60 (s, 3H). MS m/z 417 (M+1).

Provenance & Evidence