Triethylamine → HCID 58711987, compound

Participants

Reaction Steps

In a similar manner as described for Intermediate 18, 6-(1-aminoethyl)-N-(3,4,5-trimethoxyphenyl)-1,2,4-triazin-3-amine (Intermediate 9) (0.10 g, 033 mmol), 5-bromonicotinic acid (0.073 g, 0.36 mmol), O-(7-azabenzotriazol-1-yl-N,N,N′N′-tetramethyluronium hexafluorophospahte (0.14 g, 0.36 mmol) and triethylamine (0.10 mL, 0.72 mmol) in N,N-dimethylformamide (5 mL) gave 5-bromo-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)nicotinamide (0.15 g) as a white solid. MS m/z 489, 491 (M+1, M+3).

Provenance & Evidence