1H-1,2,4-Triazole → 7-(1,3-benzodioxol-5-yl)-5-methyl-N-(3,4,5-trimethoxy-phenyl)imidazo[5,1-f][1,2,4]triazin-2-amine

関与物質

反応手順

In a similar manner as described for Example 9, N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)-1,3-benzodioxole-5-carboxamide (Intermediate 29) (61 mg, 0.134 mmol), and 1,2,4-triazole (55 mg, 0.80 mmol) in pyridine (2 mL) and phosphorous oxychloride (0.037 mL, 0.40 mmol) gave 7-(1,3-benzodioxol-5-yl)-5-methyl-N-(3,4,5-trimethoxy-phenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (25 mg, 43%) as a yellow solid. 1H NMR (CD3OD): δ8.99 (s, 1H), 7.87 (s, 1H), 7.84 (d, J=1.65 Hz, 1H), 7.04 (s, 2H), 6.95 (d, J=7.87 Hz, 1H), 6.04 (s, 2H), 3.80 (s, 6H), 3.74 (s, 3H), 2.56 (s, 3H). MS m/z 435 (M+1).

情報源と証拠