1H-1,2,4-Triazole → HCID 135545443, compound

Participants

Reaction Steps

In a similar manner as described for Example 9, N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)-1H-indole-2-carboxamide (Intermediate 33) (219 mg, 0.491 mmol), and 1,2,4-triazole (210 mg, 3.0 mmol) in pyridine (10 mL) and phosphorous oxychloride (0.14 mL, 1.5 mmol) gave 7-(1H-indol-2-yl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (128 mg, 61%) as a yellow solid: 1H NMR (DMSO-d6): δ11.85 (s, 1H), 9.67 (s, 1H), 9.26 (s, 1H) 7.55 (s, 1H), 7.52 (d, J=8.24 Hz, 1H), 7.46 (d, J=8.24 Hz, 1H), 7.21 (s, 2H), 7.15 (t, J=7.51, 1H), 7.04 (t, J=7.51 Hz, 1H), 3.82 (s, 6H), 3.68 (s, 3H), 2.58 (s, 3H). MS m/z 430 (M+1).

Provenance & Evidence