1H-1,2,4-Triazole → HCID 11396293, compound

Participants

Reaction Steps

In a similar manner as described for Example 9, N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)-1H-indole-5-carboxamide (Intermediate 38) (176 mg, 0.39 mmol), and 1,2,4-triazole (161 mg, 2.34 mmol) in pyridine (4 mL) and phosphorous oxychloride (0.11 mL, 1.2 mmol) gave 7-(1H-indol-5-yl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (63 mg, 37%) as a yellow solid. 1H NMR (CDCl3): δ8.87 (s, 1H), 8.79 (s, 1H), 8.35 (s, 1H), 8.29 (dd, J=8.61 and 1.46 Hz, 1H), 7.47 (d, J=8.61 Hz, 1H), 6.95 (s, 2H), 6.84 (s, 1H), 6.62 (s, 1H), 3.87 (s, 3H), 3.77 (s, 6H), 2.64 (s, 3H). MS m/z 430 (M+1).

Provenance & Evidence