1H-1,2,4-Triazole → HCID 11752796, compound

Participants

Reaction Steps

In a similar manner as described for Example 9, 2-[(2-cyanophenyl)thio]-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (Intermediate 39) (269 mg, 0.49 mmol), and 1,2,4-triazole (210 mg, 2.94 mmol) in pyridine (3 mL) and phosphorous oxychloride (0.14 mL, 1.5 mmol) gave 2-[(2-{5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-7-yl}phenyl)thio]benzonitrile (95 mg, 37%) as a yellow solid. 1H NMR (CDCl3): δ8.77 (s, 1H), 7.70 (m, 1H), 7.57 (m, 1H), 7.42-7.47 (m, 3H), 7.10-7.23 (m, 3H), 6.85 (s, 1H), 6.79 (s, 2H), 3.80 (s, 3H), 3.63 (s, 6H), 2.57 (s, 3H). MS m/z 524 (M+1).

Provenance & Evidence