Phosphorus oxychloride → HCID 58712007, compound

Participants

Reaction Steps

In a similar manner as described for Example 1, N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)quinoline-8-carboxamide (Intermediate 41) (0.080 g, 0.17 mmol) in 1,2-dichloroethane (5 mL) and phosphorus oxychloride (0.13 mL, 1.4 mmol) gave 5-methyl-7-quinolin-8-yl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (0.022 g) as a yellow solid. 1H NMR (CDCl3): δ8.90 (dd, J=4.2, 1.8 Hz, 1H), 8.83 (s, 1H), 8.22 (dd, J=8.3, 1.8 Hz, 1H), 8.03 (dd, J=7.2, 1.5 Hz, 1H), 7.97 (dd, J=8.2, 1.5 Hz, 1H), 7.67 (dd, J=8.2, 7.1 Hz, 1H), 7.45-7.41 (m, 1H), 6.91 (bs, 1H), 6.58 (s, 2H), 3.69 (s, 3H), 3.25 (s, 6H), 2.67 (s, 3H). MS m/z 443 (M+1).

Provenance & Evidence