HCID 68872676, compound → HCID 135984674, compound

Participants

Reaction Steps

A solution of ethyl 2-oxo-3-{[3-(trifluoromethyl)benzoyl]amino}butanoate (8.75 g, 27.6 mmol) and aminoguanidine bicarbonate (3.75 g, 27.6 mmol) in EtOH(aq) (80%, 200 mL) was heated at reflux for 3h. Concentration gave crude N-[1-(3-amino-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)ethyl]-3-(trifluoromethyl)benzamide (8.34 g) as a colourless solid which was used without further purification. 1H NMR (DMSO-d6): δ8.87 (d, J=7.5 Hz, 1H), 8.23 (s, 1H), 8.20-8.15 (m, 2H), 7.93-7.89 (m, 1H), 7.75-7.69 (m, 1H), 7.00 (bs, 1H), 5.16 (p, J=7.1 Hz, 1H), 1.40 (d, J=7.1 Hz, 3H). MS m/z 326 (M−1).

Provenance & Evidence