HCID 178432500, compound → 2-Amino-5-methyl-7-[3-(trifluoromethyl)phenyl]imidazo[5,1-f][1,2,4]triazin

Participants

Reaction Steps

A mechanical mixture of 5-methyl-7-[3-(trifluoromethyl)phenyl]-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-amine (Intermediate 44) (1.30 g, 4.41 mmol) and Pd/C (0.50 g) in EtOH (250 mL) was heated at reflux for 7 days. The reaction mixture was then cooled to rt and filtered through celite. Concentration of the filtrate followed by purification of the residue by chromatography afforded 5-methyl-7-[3-(trifluoromethyl)phenyl]-imidazo[5,1-f][1,2,4]triazin-2-amine (0.50 g) as a pale yellow solid. 1H NMR (Acetone-d6): δ9.06 (s, 1H), 8.94 (s, 1H), 8.92-8.86 (m, 1H), 7.75-7.69 (m, 2H), 6.29 (bs, 2H), 2.55 (s, 3H). MS m/z 292 (M−1).

Provenance & Evidence