4-Bromophenol → HCID 11222877, compound

Participants

Reaction Steps

In a similar manner as described for Example 41, 5-methyl-7-[3-(trifluoromethyl)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (Intermediate 45) (0.025 g, 0.09 mmol), 4-bromophenol (0.015 g, 0.09 mmol), Pd2(dba)3 (0.008 g, 0.01 mmol), 2-(Di-t-butylphosphino)biphenyl (0.008 g, 0.03 mmol), and NaOtBu (0.011 g, 0.11 mmol) in 1,4-dioxane (1 mL) gave 4-({5-methyl-7-[3-(trifluoromethyl)phenyl]imidazo[5,1-f][1,2,4]triazin-2-yl}amino)phenol (0.020 g) as a yellow solid. 1H NMR (Acetone-d6): δ9.06 (s, 1H), 8.91 (s, 1H), 8.68 (d, J=4.8 Hz, 1H), 7.77-7.70 (m, 3H), 7.59 (d, J=8.4 Hz, 2H), 6.84 (d, J=8.4 Hz, 2H), 2.55 (s, 3H). MS m/z 386 (M+1).

Provenance & Evidence