3-Bromothiophene-2-carboxylic acid → 3-bromo-N-[1-(3-{[4-(methyloxy)phenyl]amino}1,2,4-triazin-6-yl)ethyl]-2-thiophenecarboxamide

Participants

Reaction Steps

In a similar manner as described for Intermediate 48, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and 3-bromothiophene-2-carboxylic acid (93 mg, 0.45 mmol), except the reaction was stirred for 6.5 h and purification using silica SPE was omitted, to give 3-bromo-N-[1-(3-{[4-(methyloxy)phenyl]amino}1,2,4-triazin-6-yl)ethyl]-2-thiophenecarboxamide (162 mg) as a yellow solid. MS m/z 434/436 (M+1).

Provenance & Evidence