Oxane-4-carboxylic acid → N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide

Participants

Reaction Steps

In a similar manner as described for Intermediate 49, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and tetrahydropyran-4-yl-carboxylic acid (58 mg, 0.45 mmol), except the reaction was stirred for 16.5 h and a 10 g SCX cartridge was used, to give N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide (81 mg) as a yellow solid. MS m/z 358 (M+1).

Provenance & Evidence