Phosphorus oxychloride → 5-methyl-N-[4-(methyloxy)phenyl]-7-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-2-amine

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Reaction Steps

Applying the Cyclization Procedure 1, using N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide (Intermediate 50) (81 mg, 0.23 mmol), 1,2-dichloroethane (4.5 mL) and phosphorus oxychloride (0.169 mL, 1.81 mmol), to afford 5-methyl-N-[4-(methyloxy)phenyl]-7-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-2-amine (35 mg) as a yellow solid. MS m/z 340 (M+1).

Provenance & Evidence