Phosphorus oxychloride → 5-methyl-7-[2-(methyloxy)phenyl]-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine

Participants

Reaction Steps

Applying the Cyclization Procedure 1, 2-(methyloxy)-N[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (Intermediate 51) (145 mg, 0.38 mmol), 1,2-dichloroethane (4.5 mL) and phosphorus oxychloride (0.285+0.178 mL, 4.97 mmol), to afford 5-methyl-7-[2-(methyloxy)phenyl]-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (21 mg) as a yellow solid. MS m/z 362 (M+1).

Provenance & Evidence