HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 5-methyl-7-[3-(methyloxy)phenyl]-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-(methyloxy)-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide | HCID 58711935 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 5-methyl-7-[3-(methyloxy)phenyl]-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine | HCID 11187563 | 30.2% |
Reaction Steps
Applying the Cyclization Procedure 1, 3-(methyloxy)-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (Intermediate 52) (41 mg, 0.11 mmol), 1,2-dichloroethane (2.2 mL) and phosphorus oxychloride (0.081 mL, 0.87 mmol), to afford 5-methyl-7-[3-(methyloxy)phenyl]-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (12 mg) as a yellow solid. MS m/z 362 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462614B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-738d3911bd7c4d188d4f27ab0288b078 |
| Source note | uspto-grants-2008_12 |