2-Chlorobenzoic Acid → 2-chloro-N-(1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-Chlorobenzoic Acid	HCID 8374	—
Reactant	N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide	HCID 58711939	—
Reactant	6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine	HCID 58711999	—
Product	2-chloro-N-(1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide	HCID 58711993	80.7%

Reaction Steps

In a similar manner as described for Intermediate 50, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and 2-chlorobenzoic acid (70 mg, 0.45 mmol) to give 2-chloro-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (127 mg) as a yellow solid. MS m/z 384 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07462614B2
Source dataset	uspto-grants-2008_12
ORD ID	ord-7f9c5f1ca29b471c85201cc56f7aa9a0
Source note	uspto-grants-2008_12