Phosphorus oxychloride → 7-(2-chlorophenyl)-5-methyl-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine

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Reaction Steps

Applying the Cyclization Procedure 1, 2-chloro-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (Intermediate 53) (127 mg, 0.33 mmol), 1,2-dichloroethane (6.6 mL) and phosphorus oxychloride (0.250+0.154 mL, 4.33 mmol), to afford 7-(2-chlorophenyl)-5-methyl-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (39 mg) as a yellow solid. MS m/z 366 (M+1).

Provenance & Evidence