HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylindole-3-carboxylic acid → 1-methyl-N-[1-(3-{[4-(methyloxy)phenyl]amino)-1,2,4-triazin-6-yl)ethyl]-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylindole-3-carboxylic acid | HCID 854040 | — |
| Reactant | N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide | HCID 58711939 | — |
| Reactant | 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine | HCID 58711999 | — |
| Product | 1-methyl-N-[1-(3-{[4-(methyloxy)phenyl]amino)-1,2,4-triazin-6-yl)ethyl]-1H-indole-3-carboxamide | HCID 58711929 | 64.8% |
Reaction Steps
In a similar manner as described for Intermediate 50, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and 1-methyl-1h-indole-3-carboxylic acid (79 mg, 0.45 mmol) to give 1-methyl-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-1H-indole-3-carboxamide (107 mg) as a yellow solid. MS m/z 403 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462614B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-213c36396ee447769710e3feaba67bb0 |
| Source note | uspto-grants-2008_12 |