2-Phenylpropionic acid → N-[1-(3-{[4-(methyloxy)phenyl]amino)-1,2,4-triazin-6-yl)ethyl]-2-phenylpropanamide

Participants

Reaction Steps

In a similar manner as described for Intermediate 50, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and 2-phenylpropionic acid (0.061 mL, 0.45 mmol), except the reaction was stirred for 15 h, to give N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-2-phenylpropanamide (134 mg) as: a yellow solid. MS m/z 376 (M−1).

Provenance & Evidence