1H-1,2,4-Triazole → 5-methyl-N-[4-(methyloxy)phenyl]-7-(1-phenylethyl)imidazo[5,1-f][1,2,4]triazin-2-amine

Participants

Reaction Steps

Applying the Cyclization Procedure 2, using N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-2-phenylpropanamide (Intermediate 55) (129 mg, 0.34 mmol), pyridine (3.4 mL), 1,2,4 triazole (71 mg, 1.03 mmol) and phosphorus oxychloride (0.048+0.048 mL, 1.03 mmol), to afford 5-methyl-N-[4-(methyloxy)phenyl]-7-(1-phenylethyl)imidazo[5,1-f][1,2,4]triazin-2-amine (15 mg) as a yellow solid. MS m/z 360 (M+1).

Provenance & Evidence