1H-Indole-2-carboxylic acid, 1-methyl- → 1-methyl-N-[1-(3-{[4-(methyloxy)phenyl]amino)-1,2,4-triazin-6-yl)ethyl]-1H-indole-2-carboxamide

Participants

Reaction Steps

In a similar manner as described for Intermediate 55, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and 1-methylindole-2-carboxylic acid (79 mg, 0.45 mmol), to give 1-methyl-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-1H-indole-2-carboxamide (158 mg) as a yellow solid. MS m/z 403 (M+1).

Provenance & Evidence