1H-1,2,4-Triazole → 5-methyl-7-(1-methyl-1H-indol-2-yl)-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine

Participants

Reaction Steps

Applying the Cyclization Procedure 2, using 1-methyl-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-1H-indole-2-carboxamide (Intermediate 56) (151 mg, 0.38 mmol), pyridine (3.7 mL), 1,2,4 triazole (78 mg, 1.13 mmol) and phosphorus oxychloride (0.052+0.052 mL, 1.12 mmol), to afford 5-methyl-7-(1-methyl-1H-indol-2-yl)-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (11 mg) as a yellow solid. MS m/z 385 (M+1).

Provenance & Evidence