3-Furoic acid → N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-3-furancarboxamide

Participants

Reaction Steps

In a similar manner as described for Intermediate 57, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and 3-furoic acid (50 mg, 0.45 mmol). Except, that during the saturated sodium bicarbonate solution wash, a solid was formed which was collected by filtration and dried to give N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-3-furancarboxamide (110 mg) as a yellow solid. MS m/z 340 (M+1).

Provenance & Evidence