Phosphorus oxychloride → HCID 58711941, compound

Participants

Reaction Steps

Applying the Cyclization Procedure 1, using N[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-2-furancarboxamide (Intermediate 59) (85 mg, 0.25 mmol), 1,2-dichloroethane (5 mL) and phosphorus oxychloride (0.19 mL, 2.04 mmol), to afford 7-(2-furanyl)-5-methyl-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (20 mg) as a yellow solid. MS m/z 322 (M+1).

Provenance & Evidence