Phosphorus oxychloride → HCID 11302158, compound

Participants

Reaction Steps

Applying the Cyclization Procedure 1, using N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]cyclohexane-carboxamide (Intermediate 63) (90 mg, 0.25 mmol), 1,2-dichloroethane (5 mL) and phosphorus oxychloride (0.25 mL, 2.68 mmol), to afford 7-cyclohexyl-5-methyl-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (28 mg) as a yellow solid. 1H NMR (DMSO): δ9.46 (s, 1H), 9.06 (s, 1H), 7.71 (d, J=8.7 Hz, 2H), 6.91 (d, J=8.7 Hz, 2H), 3.75 (s, 3H), 3.14 (m, 1H), 2.43 (s; 3H), 1.95 (m, 2H), 1.84 (m, 2H), 1.80-1.60 (m, 3H), 1.51-1.36 (m, 2H), 1.36-1.25 (m,1H).

Provenance & Evidence