Phosphorus oxychloride → HCID 11417112, compound

Participants

Reaction Steps

Applying the Cyclization Procedure 1, using 4-(methyloxy)-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (Intermediate 65) (35 mg, 0.09 mmol), 1,2-dichloroethane (1.8 mL) and phosphorus oxychloride (0.068 mL, 0.73 mmol), to afford 5-methyl-N,7-bis[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (24 mg) as a yellow solid. MS m/z 362 (M+1).

Provenance & Evidence