Phosphorus oxychloride → HCID 58711963, compound

Participants

Reaction Steps

Applying the Cyclization Procedure 1, using 3-fluoro-N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (Intermediate 67) (130 mg, 0.35 mmol), 1,2-dichloroethane (5 mL) and phosphorus oxychloride (0.25 mL, 2.68 mmol), to afford 7-(3-fluorophenyl)-5-methyl-N-[4-(methyloxy)phenyl]imidazo[5,1-f][1,2,4]triazin-2-amine (25 mg) as a yellow solid. MS m/z 350 (M+1).

Provenance & Evidence