Phosphorus oxychloride → HCID 58711936, compound

Participants

Reaction Steps

Applying the Cyclization Procedure 1, using N-[1-(3-{[3,4,5-tris(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]cyclohexane-carboxamide (Intermediate 68) (140 mg, 0.34 mmol), 1,2-dichloroethane (5 mL) and phosphorus oxychloride (0.25 mL, 2.68 mmol), to afford 7-cyclohexyl-5-methyl-N-[3,4,5-tris(methyloxy)phenyl]-imidazo[5,1-f][1,2,4]triazin-2-amine (35 mg) as a yellow solid. MS m/z 398 (M+1).

Provenance & Evidence