HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 5-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 58711952 | HCID 58711952 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 5-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471832 | 63.5% |
Reaction Steps
Applying the Cyclization Procedure 1, using N-{1-[3-(methylthio)-1,2,4-triazin-6-yl]ethyl}benzamide (Intermediate 70) (590 mg, 2.15 mmol), 1,2-dichloroethane (10 mL) and phosphorus oxychloride (1.60 mL, 17.17 mmol), to afford 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (350 mg) as a yellow solid. MS m/z 257 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462614B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-845922fe9d5445cab18b518485dac14a |
| Source note | uspto-grants-2008_12 |