HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dimethoxyaniline → N-[3,4-bis(methyloxy)phenyl]-5-methyl-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dimethoxyaniline | HCID 22770 | — |
| Reactant | 5-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471832 | — |
| Reactant | 5-Methyl-2-(methylsulfonyl)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[3,4-bis(methyloxy)phenyl]-5-methyl-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine | HCID 11405758 | 36.6% |
Reaction Steps
Applying the displacement procedure, using 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (Intermediate 72) (50 mg, 0.17 mmol), 3,4-dimethoxyaniline (26.5 mg, 0.17 mmol) and ethanol (2.5 mL) to afford N-[3,4-bis(methyloxy)phenyl]-5-methyl-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine (22.5 mg) as a yellow solid. MS m/z 362 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462614B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-e5c039399f834a8f8316774027d03abc |
| Source note | uspto-grants-2008_12 |