HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Methylthio)aniline → 5-methyl-N-[4-(methylthio)phenyl]-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Methylthio)aniline | HCID 66038 | — |
| Reactant | 5-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471832 | — |
| Reactant | 5-Methyl-2-(methylsulfonyl)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-methyl-N-[4-(methylthio)phenyl]-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine | HCID 11152214 | 50.8% |
Reaction Steps
Applying the displacement procedure, using 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (Intermediate 72) (50 mg, 0.17 mmol), 4-(methylthio)aniline (0.022 mL, 0.17 mmol) and ethanol (2.5 mL) to afford 5-methyl-N-[4-(methylthio)phenyl]-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine (30 mg) as a yellow solid. MS m/z 348 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462614B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-338acdcf23ff4d42a0767d175d1d7585 |
| Source note | uspto-grants-2008_12 |