HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[2-(Dimethylamino)ethoxy]aniline → N-(4-{[2-(dimethylamino)ethyl]oxy}-phenyl)-5-methyl-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[2-(Dimethylamino)ethoxy]aniline | HCID 6484655 | — |
| Reactant | 5-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471832 | — |
| Reactant | 5-Methyl-2-(methylsulfonyl)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(4-{[2-(dimethylamino)ethyl]oxy}-phenyl)-5-methyl-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine | HCID 11372661 | 24.2% |
Reaction Steps
Applying the displacement procedure, using 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (Intermediate 72) (50 mg, 0.17 mmol), {2-[(4-aminophenyl)oxy]ethyl}dimethylamine (32 mg, 0.17 mmol) and ethanol (2.5 mL) to afford N-(4-{[2-(dimethylamino)ethyl]oxy}-phenyl)-5-methyl-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine (16 mg) as a yellow solid. MS m/z 389 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462614B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-6ef7a0e7dc3348faadedbad2a55eb0e7 |
| Source note | uspto-grants-2008_12 |