Triethylamine → HCID 58711981, compound

Participants

Reaction Steps

Applying the displacement procedure, using 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (Intermediate 72) (45 mg, 0.16 mmol), cyclohexylamine hydrochloride (21.5 mg, 0.16 mmol) and ethanol (2.5 mL) except that after 1 h, the mixture was treated with triethylamine (0.022 mL, 0.16 mmol), and heating continued for 0.5 h, to afford 5-methyl-7-phenyl-N-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-2-amine (15 mg) as a yellow solid. MS m/z 310 (M+1).

Provenance & Evidence