4-(2-Morpholinoethoxy)aniline → HCID 11453203, compound

Participants

Role	Name	HCID	Charge
Reactant	4-(2-Morpholinoethoxy)aniline	HCID 6484711	—
Reactant	5-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazine	HCID 53471832	—
Reactant	5-Methyl-2-(methylsulfonyl)-7-phenylimidazo[5,1-F][1,2,4]triazine	HCID 53471833	—
Solvent	Ethanol	HCID 702	—
Product	HCID 11453203	HCID 11453203	39.6%

Reaction Steps

Applying the displacement procedure, using 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (Intermediate 72) (50 mg, 0.17 mmol), (4-{[2-(4-morpholinyl)ethyl]oxy}phenyl)amine (38.5 mg, 0.17 mmol) and ethanol (2.5 mL) to afford 5-methyl-N-(4-{[2-(4-morpholinyl)ethyl]oxy}phenyl)-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine (29 mg) as a yellow solid. MS m/z 431 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07462614B2
Source dataset	uspto-grants-2008_12
ORD ID	ord-b8a87db4abfd497cbb50aa5df9a305c0
Source note	uspto-grants-2008_12