HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Morpholin-4-ylethoxy)aniline → 5-methyl-N-(3-{[2-(4-morpholinyl)ethyl]oxy}phenyl)-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Morpholin-4-ylethoxy)aniline | HCID 6486616 | — |
| Reactant | 5-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471832 | — |
| Reactant | 5-Methyl-2-(methylsulfonyl)-7-phenylimidazo[5,1-F][1,2,4]triazine | HCID 53471833 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-methyl-N-(3-{[2-(4-morpholinyl)ethyl]oxy}phenyl)-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine | HCID 11475926 | 24.6% |
Reaction Steps
Applying the displacement procedure, using 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (Intermediate 72) (50 mg, 0.17 mmol), (3-{[2-(4-morpholinyl)ethyl]oxy}phenyl)amine (38 mg, 0.17 mmol) and ethanol (2.5 mL) to afford 5-methyl-N-(3-{[2-(4-morpholinyl)ethyl]oxy}phenyl)-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine (18 mg) as a yellow solid. MS m/z 431 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462614B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-5a2bf839a9d1462ab2acc975c24ee2b1 |
| Source note | uspto-grants-2008_12 |