3-Methoxyaniline → HCID 58711928, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-{1-[3-(methylsulfonyl)-1,2,4-triazin-6-yl]ethyl}benzamide (Intermediate 73) (100 mg) and m-anisidine (1 mL) was heated at 50° C. overnight. The crude reaction mixture was then purified by chromatography on silica gel eluting with 30% ethyl acetate in petrol to give N-[1-(3-{[3-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide as a yellow solid (35 mg). 1H NMR (CDCl3): δ8.39 (s, 1H), 7.82 (m, 2H), 7.51-7.32 (m, 5H), 7.28-7.13 (m, 3H), 6.68 (m, 1H) 5.47 (m, 1H), 3.84 (s, 3H), 1.70 (d, J=6.9 Hz, 3H).

Provenance & Evidence