Phosphorus oxychloride → HCID 11174936, compound

Participants

Reaction Steps

Applying the Cyclization Procedure 1, using N-[1-(3-{[3-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (Intermediate 74) (55 mg, 0.16 mmol), 1,2-dichloroethane (5 mL) and phosphorus oxychloride (0.20 mL, 2.14 mmol), to afford 5-methyl-N-[3-(methyloxy)phenyl]-7-phenylimidazo[5,1-f][1,2,4]triazin-2-amine (3 mg) as a yellow solid. MS m/z 332 (M+1).

Provenance & Evidence