HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Dimethylethyl (1R)-1-(naphthalen-2-ylmethyl)-2-oxo-2-[(6-oxo-2-phenyl-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)amino]ethylcarbamate | HCID 136181647 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2r)-2-Amino-3-naphthalen-2-yl-n-(6-oxo-2-phenyl-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)propanamide hydrochloride | HCID 136401960 | 99% |
Reaction Steps
Preparation of example 176 from the title compound of Example 154 (59 mg, 0.103 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (52 mg, 0.102 mmol) as an orange/yellow powder in 99% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462713B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-7cf9431cf1964ceeb2131b924d7b4d8f |
| Source note | uspto-grants-2008_12 |