Sodium Hydroxide → 2'-Methoxy-biphenyl-4-carboxylic acid

HRID 2375147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2375147
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+]>O1CCCC1>[CH3:19][O:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:9]1[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 438402982'-Methoxy-biphenyl-4-carboxylic acid ethyl ester

Produkt 1

HCID 27595482'-Methoxy-biphenyl-4-carboxylic acidAusbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 2′-methoxy-[1,1′-biphenyl]-4-carboxylic acid ethyl ester of Step A (3.7 g, 14.4 mmol) in tetrahydrofuran (40 mL) and 1 N sodium hydroxide (30 mL, 30 mmol) was heated at reflux overnight. After cooling, the reaction mixture was concentrated in vacuo, and the residue was acidified with 2N hydrochloric acid to give a white solid which was collected by filtration and dried under vacuum to provide the title compound (3.2 g, 97.4%) as a white solid, m.p. 250-253° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. temperatureAfter cooling
  4. concentrationthe reaction mixture was concentrated in vacuo
  5. customto give a white solid which
  6. filtrationwas collected by filtration
  7. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e8f153600dc04d8598e4be415be87c6c
Quelldatensatz
uspto-grants-2008_12
Patentnummer
US07465722B2

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