Hydrazine → HCID 12986831, compound

HRID 2375174Notes

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH3:26])[CH:18]=2)[N:3]=1.[NH2:27][NH2:28]>>[CH3:26][O:25][C:19]1[CH:18]=[C:17]([CH2:16][CH2:15][CH2:14][C:4]2[N:3]=[C:2]([NH:27][NH2:28])[CH:7]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:5]=2)[CH:22]=[CH:21][C:20]=1[O:23][CH3:24]

Participants

Reactant 2

HCID 9321Hydrazine

HCID 12986830HCID 12986830, compound

Product 1

HCID 12986831HCID 12986831, compoundYield 89%

Procedure

Further, 4-chloro-2-[3-(3,4-dimethoxyphenyl)propyl]-6-morpholinopyrimidine (0.34 g, 0.90 mmol) was reacted with hydrazine (0.29 g, 9 mmol) to obtain 2-[3-(3,4-dimethoxyphenyl)propyl]-4-hydrazino-6-morpholinopyrimidine as a white solid (0.30 g, 0.80 mmol, 89%).

Sources & evidence

ORD record: ord-827aaad076c74a3e9ee698c693d3a1fe
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07465725B2

Reaction notes

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