Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 11327963 | HCID 11327963 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | HCID 59833615 | HCID 59833615 | 55.8% |
Reaction Steps
294 mg (1.30 mmol) of sodium methoxide (90% in methanol) were added to a solution of 282 mg (0.65 mmol) of sulfone 1 in 4 ml of anhydrous DMF. The mixture was stirred at 20-25° C. for 16 hours and then diluted with MTBE, washed with water and dried. Distillative removal of the solvent and chromatography on silica gel gave 0.14 g of the title compound of m.p. 121-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07465735B2 |
|---|
| Source dataset | uspto-grants-2008_12 |
|---|
| ORD ID | ord-e56c692480fe4dd5b9ec4af0a7258ca0 |
|---|
| Source note | uspto-grants-2008_12 |
|---|
