4-(N-Boc-amino)piperidine → HCID 86608431, compound

HRID 2375252Notes

Reaction equation

HRID 2375252 reaction equation
[O:1]1[CH:11]2[CH:2]1[CH2:3][O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=12.[NH:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:14][CH2:13]1>C(#N)C>[OH:1][C@H:2]1[C@H:11]([N:12]2[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[CH2:16][CH2:17]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[O:4][CH2:3]1

Participants

4

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 131490333,6-Dioxatricyclo[5.4.0.0,2,4]undeca-1(11),7,9-triene

Product 1

HCID 86608431HCID 86608431, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 3 g of the compound obtained in Step B of Example 4, dissolved in 45 ml of acetonitrile, there are added 4 g of tert-butyl piperidin-4-ylcarbamate (20.2 mmol). The mixture is then heated at reflux for 12 hours and subsequently evaporated to dryness. A yellow oil is obtained which is purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5) to yield the expected product in the form of a pale-yellow meringue.

Workup

  1. temperatureThe mixture is then heated
  2. temperatureat reflux for 12 hours
  3. customsubsequently evaporated to dryness
  4. customA yellow oil is obtained which
  5. customis purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5)

Sources & evidence

ORD record
ord-af751b25057342d699ad7c16b3583d90
Source dataset
uspto-grants-2008_12
Patent number
US07465733B2

Reaction notes

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