反应详情

To 3 g of the compound obtained in Step B of Example 4, dissolved in 45 ml of acetonitrile, there are added 4 g of tert-butyl piperidin-4-ylcarbamate (20.2 mmol). The mixture is then heated at reflux for 12 hours and subsequently evaporated to dryness. A yellow oil is obtained which is purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5) to yield the expected product in the form of a pale-yellow meringue.

1. temperatureThe mixture is then heated
2. temperatureat reflux for 12 hours
3. customsubsequently evaporated to dryness
4. customA yellow oil is obtained which
5. customis purified by flash chromatography on silica (eluant: dichloromethane/ethanol 95/5)