Triethylamine → 1,3-Dimethoxypropan-2-yl methanesulfonate

Participants

Reaction Steps

To a solution of 1,3-dimethoxy-2-hydroxypropane (3.84 g, 0.032 mol) in DCM (70 ml) cooled at 5° C. was added triethylamine (5 ml, 0.036 mol) followed by slow addition of methanesulphonyl chloride (2.72 ml, 0.035 mol). The mixture was then stirred at ambient temperature for 24 hours. The mixture was then absorbed onto silica gel and purified by flash silica chromatography DCM:isohexane (3:1) to give the title compound (3.74 g, 59%). NMR 3.15 (s, 3H), 3.28 (s, 6H), 3.52 (d, 4H), 4.78 (q, 1H).

Provenance & Evidence