Ethylenediamine → 6-[(2-Aminoethyl)amino]pyridine-3-carbonitrile

Participants

Reaction Conditions

Reaction Steps

To 100 mL of ethylene diamine at 50° C. under nitrogen was added 2-chloro-5-cyanopyridine (10 g, 0.0722 mol) in small portions over a period of 3 h. The reaction mixture was stirred at 50° C. for an additional 5 h. The reaction mixture was concentrated to near dryness under reduced pressure and the crude residue obtained was purified by chromatography using chloroform/methanol (9/1) as eluent to afford 9 g of the title compound as a solid (77%).

Provenance & Evidence