Acrylonitrile → 3-(1H-1,2,4-Triazol-1-yl)propanenitrile

HRID 2375306Notes

Reaction equation

HRID 2375306 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[C:6](#[N:9])[CH:7]=[CH2:8]>>[N:1]1([CH2:8][CH2:7][C:6]#[N:9])[CH:5]=[N:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 7855AcrylonitrileHCID 92571H-1,2,4-Triazole

Product 1

HCID 132710943-(1H-1,2,4-Triazol-1-yl)propanenitrile

Conditions

Temperature
80 °C

Procedure

A mixture of 1,2,4-triazole (25 g, 0.362 mol) and acrylonitrile (100 mL, 4 w/v) was heated up to 80° C. under nitrogen for 16 h. The reaction mixture was then concentrated under reduced pressure to remove the excess of acrylonitrile affording 41 g of the title compound as a colourless liquid (93%). It was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customto remove the excess of acrylonitrile affording 41 g of the title compound as a colourless liquid (93%)
  3. customIt was used in the next step without further purification

Sources & evidence

ORD record
ord-046b69985bb44139981b56b3f09e19fd
Source dataset
uspto-grants-2008_12
Patent number
US07465736B2

Reaction notes

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