Dimethylamine → HCID 74344756, compound

Participants

Reaction Steps

To a solution of dimethylamine (0.051 mL, 1 mmol) in DCE was added a solution of TMA 2M in hexane (499 mmol, 1 mmol) and the mixture was stirred 30 min at r.t. To this solution was added a solution of methyl N-{4-[(4-tert-butyl-1,3-thiazol-2(3H)-ylidene)(cyano)methyl]pyrimidin-2-yl}-beta-alaninate (72 mg, 0.2 mmol) in DCE and the mixture was refluxed under inert atmosphere overnight then stirred for a week at r.t. The mixture was diluted with DCM then water was added. The suspension was filtered through celite. The filtrate was washed with aqueous NaHCO3 5% (×2) then brine and it was dried over MgSO4. The solvent was removed under reduced pressure affording the title compound as yellow solid (HPLC max plot 86%).

Provenance & Evidence