Phenol → HCID 59854780, compound

Participants

Reaction Steps

3-Benzyl-8-chloro-4-oxo-2-(3,4,5-trimethoxyphenyl)-3,4,5,6-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine-7-carbaldehyde (Compound No. 3) (50 mg, 96 μmol), phenol (13.5 mg, 143.4 μmol), KOH powder (8.0 mg, 143.4 μmol) and TBAB (1.0 mg) were heated at 85° C. for five hours and at 60° C. for 4,5 hours. The reaction mixture was filtered through cotton wool and evaporated. The crude product was purified by flash-chromatography. The compound No. 5 was isolated as a by-product.

Provenance & Evidence