Sodium Hydroxide → HCID 178481682, compound

Participants

Reaction Steps

2-(1-Benzothien-2-ylcarbonyl)-N-methylhydrazine-carbothioamide (15.30 mmol, 4.06 g) and 50 ml of 2N sodium hydroxide solution were heated to reflux for 8 h. The reaction mixture was diluted with water and extracted three times with ethyl acetate. The aqueous phase was acidified with 2N hydrochloric acid and extracted with dichloromethane. The crude product obtained after drying and concentration of the organic phase was purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 6:4), resulting in 2.2 g of the title compound.

Provenance & Evidence