1-[2-(3-chloropropyl)-2,3-dihydro-1H-isoindol-5-yl]propan-1-one → 1-(2-{3-[(4-Methyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]propyl}-2,3-dihydro-1H-isoindol-5-yl)propan-1-one hydrochloride

Participants

Reaction Steps

The title compound was prepared in analogy to method 1.5 from 4-methyl-5-phenyl-4H-1,2,4-triazole-3-thiol (1.43 mmol, 0.33 g) and 1-[2-(3-chloropropyl)-2,3-dihydro-1H-isoindol-5-yl]propan-1-one (1.43 mmol, 0.36 g; preparation in analogy to 1.4 from isoindoline as disclosed in WO 0125200). Yield: 0.24 g.

Provenance & Evidence